지난 강의 Principles of Clinical Systems Biology · 4/6회차
Mitochondrial Dysfunction and Metabolic Imbalance in Chronic Disease
- 일시
- 2026.08.30(일요일)
- 회차 · 장소
- 총 4/6회 익산 유스호스텔
상세 커리큘럼
I. Key Role of Mitochondrial Function, Biology in Health and Disease
- Energy Production (ATP Synthesis)
- Intrinsic Metabolism and Biosynthesis
- Cellular Signaling and Homeostasis
- Calcium Homeostasis, Reactive Oxygen Species Signaling
- Immune Signaling and Defense;
- Mitochondrial dynamics and Mitochondrial Quality Control
- Regulation of Cell Death
- Integrative view: maintenance of cellular homeostasis and stress adaptation
- Mitochondrial stress responses: adaptive vs maladaptive stress responses
- Energetic and neuroendocrine immune view of stress responses
- Mitochondrial Uncoupling in Mitochondrial Stress Response: A Key Controller of Biological Processes in Physiology and Diseases
- Proton leak: basal vs induced
- Physiologic functions and isoforms of UCP
- Cellular Responses to Mitochondrial Uncoupling
- Signaling Molecules in Mitochondrial Stress Response
II. Overview of mitochondrial dysfunction
- Definition and difference between metabolic imbalance mitochondrial dysfunction
- Pathogenetic roles of mitochondrial dysfunction in chronic diseases
- Mitochondrial Dysfunction in Chronic Inflammatory Diseases
- Metabolic reprogramming in mitochondrial dysfunction
- Immune cell alteration in mitochondrial dysfunction
- Metabolic syndrome can aggravate chronic inflammatory diseases
- Mitochondrial dysfunction related chronic diseases
- Primary Mitochondrial Diseases AI
- Acquired mitochondrial dysfunction: a common root of noncommunicable chronic diseases
- Chronic Inflammatory Diseases
- Immune diseases
- Autoimmune diseases
- Allergic diseases
- Mitochondrial dysfunction in metabolic diseases
- Responses of mitochondrial dysfunction in metabolic imbalance
- Metabolic reprogramming drives metabolic-inflammatory syndrome
- Key Disease Associations
- Key Manifestations in Specific Conditions
- Metabolic syndrome can aggravate chronic inflammatory diseases
- Metabolic Disorders and Fibrosis
- Mitochondrial dysfunction in cardiovascular disease
- Heart failure
- Atherosclerosis
- Atrial fibrillation
- Chronic lung disease and mitochondrial dysfunction
- Chronic bone and joint disease, and mitochondrial dysfunction
- Mitochondrial dysfunction in CFS, Myalgic encephalomyelitis
- Mitochondrial dysfunction, Driver of chronic pain, Fibromyalgia
- Chronic neuroinflammatory diseases and mitochondrial dysfunction
- Mitochondrial UCPs in chronic neuroinflammatory diseases
- Microglial cell metabolic reprogramming and neuroinflammation
- Mitochondrial dysfunction in chronic neuroinflammatory diseases:
- Neurodegeneration
- Mental disorders and brain function
- Peripheral Mitochondrial Dysfunction
- Aging, age-related disorders,
- Mitochondrial dysfunction is one of the key hallmarks of aging process
- Deregulated metabolic remodeling or chronic inflammation is considered a critical biological factor in ageing and chronic age-related diseases
- Pro-Aging Metabolic Reprogramming: A Unified Theory of Aging
- Metabolic reprogramming: a bridge between aging and tumorigenesis
- Cancer and mitochondria dysfunction
- Metabolic reprogramming
- Genetic and epigenetic alterations in mitochondrial and nuclear DNA
- Excess mitochondrial ROS attacks nuclear and mitochondrial DNA
- Retrograde signaling: gene expression to promote survival under stress
- Heterogeneous Mitochondrial dysfunction
- Within the tumor microenvironment
- Suppress immune responses and Immune Evasion
- Mediate stromal cell functions.
III. ATM: Causes of mitochondria dysfunction
- Inherited genetic mutations (primary mitochondrial disease)
- Acquired damage from environmental stress, toxins, aging, or prolonged exposure to excess nutrients.
- Chronic Infection
- Noncommunicable chronic diseases
- Genomic susceptibility, early-life stress, developmental influences and aging
- The NEI-Mitochondrial Connection: How It Works
- Neuroendocrine immune connection
- Immunometabolism, Oxidative stress (Redox imbalance)
- Gut dysfunction, Food sensitivities and allergens
- Metabolic stressors, obesity, MBS
- Nutrition
- Environmental Toxins
- Lifestyle:
IV. Functional Medicine Approach to Mitochondrial Health
- Detailed health history and lifestyle assessment
- Laboratory testing for
- Comprehensive Metabolic Panel including fasting glucose, insulin, HOMA-IR, HbA1c, lipid particle size, adiponectin, and inflammatory markers Ferritin, Vitamin D, sCRP
- Infection
- FM lab
- Organic Acids Test (OAT):.
- Nutrient levels,
- oxidative stress markers, and mtDNA integrity
- CoQ10 (Plasma), Carnitine (Plasma), RBC Magnesium, Fatty acid profile
- MitoSwab Test
- Comprehensive Stool Test (GI MAP) Plus Zonulin
- DUTCH Plus Complete Test + Cortisol Awakening Response
- Nutrient Tests
- Assessment of environmental exposures and toxin burdens, HM Panel
- Genetic Testing
- How to Interpret These Labs Together
- Organic Acids Test (OAT):.
- 예제 풀이
V. Functional medicine approach to mitochondrial dysfunction
- Symptomatic Tx
- Mitochondrial restoration: Boost and protect the mito function via endogenous defense mechanisms
- Supplements Modulating endogenous cellular defense mechanisms
- ↑Mitochondrial biogenesis: Resveratrol, curcumin
- Mitochondria-target antioxidants
- Mitochondrial nutrients: Coenzyme Q10 (100 mg QD), 100mg x 3 / day, Magnesium
- Hormetic lifestyle change
- Hormetic Diet:
- Adequate exercise
- Appropriate sleep
- stress management and Social / spiritual support
- Hot and cold temperatures: Saunas
- Advanced Therapy
- Dietary restriction: Calorie restriction/fasting, Ketogenic diet:
- Integrative Therapies: Light therapy and photobiomodulation, Hyperbaric oxygen therapy
- Supplements Modulating endogenous cellular defense mechanisms
- Adress Underlying causes: Control Triggers/Mediators first, then Antecedents
- Rebalancing NEI interaction
- Lifestyle Interventions
- Neuromodulation
- Targeting Neuroendocrine Pathways: adaptogens, beta-blockers
- Immune system modulation: n-s FAs
- Gut Microbiota Modulation
- Adress food sensitivity/allergy
- Target nutritional Tx
- Adress environmental toxicity: Mitochondrial Detox
- Control chronic infections
- Lifestyle modification: SAD diet, sedentary life, sleep, stress reduction,
- Adress structural imbalance
- Rebalancing NEI interaction
- Regenerative Therapies to restore the mitochondrial function and improve the overall health.
- Mitochondrial-targeted therapies (MTT).
Metabolic diseases and metabolic health
- Key Aspects of Metabolic Health
- Metabolic health and metabolically healthy person
- Common acquired metabolic disorders
- Pathophysiology of metabolic syndrome and related disorders
- Roles of neuroimmune endocrine controls: Maladaptive stress-related neuroendocrine response
- Autonomic dysfunction and HPA axis dysregulation with Increased adrenergic drive, ↓vagal tone, high cortisol secretion
- Immune dysfunction
- Trend in Conventional medicine
- Cardiometabolic-Based Chronic Disease:
- CV-Kidney-Metabolic Syndrome
- Cardiovascular-Endocrine-Metabolic Medicine: CardioMetabolic + EndocrineMedicine
- Roles of gut dysbiosis in metabolic syndrome
- Roles of mitochondrial dysfunction and insulin resistance in metabolic disease and central (hypothalamus and brainstem) neuroinflammation
- Roles of neuroimmune endocrine controls: Maladaptive stress-related neuroendocrine response
- Root Cause of Metabolic Disorders
- Life stress in metabolic disorders
- Infection
- Mediators
- Assessment, Diagnostic approaches
- Screening for Metabolic Syndrome
- Initial Laboratory Investigations
- Investigations for Evaluation of Complications
- FM lab
- FM management
- Symptomatic tx and supplements supporting mitochondrial restoration in MBS
- Conventional Approach To Metabolic Syndrome
- Supplements supporting mitochondrial restoration in MBS
- Adress metabolic imbalance
- Supplements
- Root-cause-focused lifestyle strategies
- Adress ATM
- Monitoring and Adjustment, Other types of therapies.
- Symptomatic tx and supplements supporting mitochondrial restoration in MBS
Systems biological Strategies for Neurodegenerative Disease
- Pathophysiology of neurodegenerative diseases
- Causes/risk factors of Neurodegenerative Diseases
- Early Symptoms of Neurodegenerative Disease
- D/D Functional neurological disorder
- Functional Medicine Lab Testing
- Systems Biological Management of Neurodegenerative Disease
- Symptomatic tx and supplements supporting mitochondrial restoration in NDD
- Conventional symptomatic treatments and their Limitations
- Supplements supporting mitochondrial restoration in NDD
- Control neuroinflammation,
- Lifestyle Interventions
- Dietary Interventions for Neurodegenerative Disease Management
- Physical Activity and Neurodegenerative Diseases
- Mind-Body Therapies
- Bioelectric Optimization
- Natural Bioelectric Optimization, ANS rebalance
- Bioelectronic techniques: VNS, transcranial magnetic stimulation
- Reduce inflammation and enhance circulation: targeting the kynurenine pathway
- Therapeutic Strategies to Balance Hormones
- Individualized brain rehabilitation
- Lifestyle Interventions
- Adress ATM
- Microbiota and gut barrier to reestablish neuroimmune homeostasis. Eliminate reactive food
- Adress metabolic imbalance
- Targeted nutritional supplementation
- Address Environmental toxicity and Infections:
- Lifestyle modification
- Other types of therapies.
- Symptomatic tx and supplements supporting mitochondrial restoration in NDD