지난 강의 Principles of Clinical Systems Biology · 2/6회차
Gut Health and Disease.
- 일시
- 2025.12.14(일요일) 09:00–17:00
- 회차 · 장소
- 총 2/6회 익산 유스호스텔
장 기능은 단순한 소화와 흡수기능 뿐 아니라 전신의 Neuroendocrine, Immune, Metabolism을 조절하여 우리 몸의 Homeostasis를 유지하기 때문에 대부분의 주요 만성질환이 소화기 기능, 특히 장내미생물의 변화에 기인합니다.
"장이 건강해야 몸이 건강하다"는 말이 있듯,
장기능을 회복하기 위해 제안된 "5R Program"이, 소화기 질환(GERD, hypochlorhydria, IBS, constipation, chronic diarrhea)의 진단과 치료에 어떻게 이용되는가를 알아보고,
전신의 주요 질병의 치료에 5R Program이 어떻게 활용되는 가도 알아보는 시간이며,
기능의학과 현대의학의 장단점을 절충한 Systems Biological Medicine의 건강관리와 질병치료 원리가 소개됩니다.
Clinical Systems Biology는 생명의 원리를 응용하는 임상의학입니다.
서 말의 구슬도 꿰어야 보석이 됩니다. 지난 10년 간의 노력으로 의학을 얼마나 체계적으로 쉽게 정리했는가를 확인해 보세요.
상세 커리큘럼
I. Key Functional Roles of the Gut and Gut Microbiome
: a central organ that maintains our health
- Understanding gut microbiome, gut ecosystem and microbial barrier
- Human gut microbiota and composition
- Symbiosis with metabolite interactions between host and microbiota
- Host diet and metabolites feed microbiota
- Microbial metabolites and products regulate host homeostasis(The major microbial metabolites, Mitochondria crosstalk, Immune/Neuroendocrine/Metabolism function, Vitamins synthesis, Xenobiotic metabolism)
- Role of the microbiome in human chronological development
- Role of gut microbiota in gut homeostasis, systemic homeostasis and pathology
- Dysbiosis: definition, types and causes
- Digestion and absorption of nutrient
- Gastric acid: Hypochlorhydria
- Bile juice: Bile insufficiency, bile acid malabsorption
- Pancreatic enzymes: Exocrine pancreatic insufficiency
- Intestinal enzymes: Lactose / fructose intolerance
- Roles of gut microbiota
- Epithelial barrier (chemical, physical) function
- Maintenance of intestinal homeostasis by mucosal barriers
- Compromised barrier leads to inflammation and disease: Leaky gut
- Gut mucosal and systemic immune system
- Gut mucosal immune system & Modulation of mucosal immune function
- Control systemic immune balance: Microbiome-immunity interaction
- Homeostasis & Regulation
- Detox: Xenobiotic/drug metabolism, Environmental pollutants
- Energy: Gut microbiota and human metabolism (Signaling, Metabolic diseases)
- Neurohormonal: Gut hormones, HPA axis, Gut-Brain Axis, Neurotransmitters, Circadian Rhythms
- Gut-organs AXIS & Organ diseases
- Gut-brain axis (Neuropsychiatric)
- Gut-liver Axis
- Gut-kidney axis
II ~ IV. Assessment & Diagnosis
- ATM: Dysbiosis, Leaky gut
- Assessment of gut function
- Health Hx: Sx/signs, Diet Hx, Antibiotics, Pets, Travelling
- Physical cues found in the mouth
- Systems biology Labs to Test for Root Cause
- Comprehensive Blood Panel
- Gut Health Testing (Digestion, Absorption)
- Microbial test (Stool, SIBO breath, OA test, Metabolites)
- Barrier tests (Permeability, Chemical, Immune)
- Case study
V. Systems biological approaches to gut dysfunction
Symptom control or Immune neuroendocrine support
- Correct GI imbalance 4R program
- Remove: Reactive foods, Pathogens (SIBO), Toxins, Stress
- Replace: Digestive secretions, replenishing nutrients
- Reinoculate: Probiotic foods or supplements
- Repair: Help the lining of the GI tract repair itself
- Rebalance: Life style modificationDiet, Exercise, Circadian Rhythms, Meditation, Avoid toxins
- Fecal microbiota transplantation (FMT)
- Correct biological systems imbalance
- Neuroendocrine / Metabolic / Nutritional / Detox imbalance
- Correct Gut-organ axis dysregulation
- Gut-kidney axis (IgA nephropathy)
- Gut-brain axis Modulation (Vagal tone, Resilience)
- GI Disorders (IBD, Ulcers, Functional GI Disorders)
VI. Systems Biological Approach to common GI disorders
- HypochlorhydriaThe Low Stomach Acid Epidemic
- What is it & Causes & Symptoms
- How to Test & Manage
- Replace HCL/Enzymes, Reinoculate
- Lifestyle changes & Diet
- GERD
- Risk factors / Causes / Diagnosis
- Treatment: PPI pros/cons
- Remove/addressing underlying causes
- Support Gut Health (Enzymes, Repair)
- IBS (Irritable Bowel Syndrome)
- Pathophysiological mechanisms (Gut-brain axis)
- Root Causes (Dysbiosis, SIBO, SIFO, Food Sensitivity)
- Functional medicine Tx (Remove, Correct imbalance)
- Supplements used to treat Gut Health & IBS
- Chronic Constipation
- Common symptoms & Causes
- Diagnosis & Functional testing
- Systems biological treatment (Remove, Correct imbalance)
- Chronic Diarrhea
- Signs & Symptoms & Causes
- Diagnostic evaluation (Organic vs Functional)
- Systems biological Approaches:
- Remove triggers
- Correct gut imbalance & Supplements
- Case study